Border Collie, Bordoodle, and Maremma Sheepdog Genetics and Health Testing
2J 2K Ranch is committed to staying updated on the latest developments in genetics. As canine genetic research and development continually advance, we ensure that our high testing standards are maintained by staying at the forefront of the latest genetic health screenings.

Understanding Canine DNA Test Results
Most of the above tests are autosomal recessive, meaning two copies of the mutated or abnormal gene must be present for the disease, trait, or disorder to develop.
A puppy inherits one copy of a gene from each parent. When no copies of an abnormal gene are in either parent, each parent and the puppy will be genetically clear. Furthermore, the entire litter from two clear parents will be clear.
Whereas when one copy of a mutation is present in one of the parents, that parent is a carrier. If one parent is clear and the other is a carrier, statistically speaking, 50 percent of their puppies will be carriers, and 50 percent will be clear.
In addition, when a dog or puppy is a carrier of an autosomal recessive gene, they will not be affected by the defective gene; they will only carry the disease.
Likewise, a dog who carries a mutation bred to a clear dog will produce no offspring affected by the disease. Moreover, only when a dog or puppy has two copies of a faulty gene (one from the father and one from the mother) will they be affected by the disease.
Most of the tests we test our dogs for are autosomal recessive. According to Casey Carl, DVM, former Associate Medical Director at Paw Print Genetics and former professional services veterinarian at Embark Veterinary, the exceptions are:
- Chondrodystrophy (CDDY and IVDD Risk): Semi-dominant for leg length decrease (one copy of mutation may shorten the leg, but two copies cause more shortening) and dominant for increased risk of IVDD.
- Multidrug Resistance 1– Autosomal Incomplete Dominant (some dogs with one copy of the mutation may have adverse drug reactions to problem drugs, and dogs with two copies are significantly affected)
- Chondrodysplasia (CDPA)- This is a trait associated with short legs. This test is included with CDDY testing when ordered from Orivet and is listed in the trait section on Canine HealthCheck. CDPA is also inherited in a semi-dominant fashion (like CDDY’s effect on leg length). However, the CDPA mutation is not associated with an increased risk of IVDD.
Keeping Carriers In The Gene Pool
When approached responsibly, breeding carriers with clear dogs contributes positively to the gene pool. Indeed, breeding healthy carrier dogs with good temperaments helps maintain genetic diversity. However, when a breeder uses only clear dogs in a breeding program, they may carry unknown mutations. Undoubtedly, they will pass these undetected defects on to their puppies, affecting future generations. Although no dog is entirely risk-free, a responsible breeder can take ethical steps to minimize the risk of known and unknown genetic mutations.
Furthermore, it is advisable to judiciously breed from geographically separated areas to create a healthier gene pool with greater genetic diversity, and to include imported dogs and dogs from different regions of countries. Additionally, there is a division within many breeds, creating subgroups such as sport, show, pet, working, hunting, service dog, livestock guardian, guard dog, etc. Introducing health-tested imported dogs or dogs from various health-tested sub-groups into a program allows a breeder to reintroduce genes, thus contributing to genetic preservation.
In conclusion, at the 2J 2K Ranch, we collaborate with industry leaders to provide our puppy families healthy, well-rounded, joyful canine family members. Notably, our dedication is to raising puppies who are healthy, well-socialized, and well-rounded, and who will grow up to be the best dogs bringing absolute delight and happiness into their owners’ lives.
Border Collie:
- Chondrodystrophy (CDDY and IVDD Risk) with or without Chondrodysplasia (CDPA)
- Collie Eye Anomaly Aliases: Choroidal hypoplasia, CEA, CH
- Degenerative Myelopathy Aliases: Canine degenerative myelopathy, DM
- Dental Hypomineralization
- Early Adult-Onset Deafness For Border Collies (Linkage test)
- Glaucoma (Border Collie Type) Aliases: BCG
- Hyperuricosuria Aliases: Urolithiasis, HUU (Hereditary Calcium Oxalate Urolithiasis Type 1)
- Intestinal Cobalamin Malabsorption (Border Collie Type) Aliases: Cobalamin deficiency, Cubilin deficiency, Imerslund-Grasbeck syndrome, I-GS
- Multidrug Resistance 1 Aliases: Ivermectin sensitivity, MDR1 gene defect, Multidrug sensitivity, MDR1
- Myotonia Congenita (Australian Cattle Dog Type) Aliases: Congenital myotonia, Inherited myotonia, Myotonia, Myotonia hereditaria
- Neuronal Ceroid Lipofuscinosis 5 (Australian Cattle Dog/Border Collie Type) Aliases: Amaurotic idiocy, Batten disease, NCL, NCL5
- Sensory Neuropathy (Border Collie Type) Aliases: SN
- Trapped Neutrophil Syndrome Aliases: Cohen syndrome, TNS
Poodle:
- Chondrodystrophy (CDDY and IVDD Risk) with or without Chondrodysplasia (CDPA)
- Degenerative Myelopathy Aliases: Canine degenerative myelopathy, DM
- Ehlers-Danlos Syndrome (Poodle Type, Variants 1 and 2)
- GM2 Gangliosidosis (Poodle Type) Aliases: Sandhoff disease, Type 0 gangliosidosis
- Hereditary Cataracts Aliases: Early-onset cataracts, Juvenile cataracts, HC, JC
- Multidrug Resistance 1 Aliases: Ivermectin sensitivity, MDR1 gene defect, Multidrug sensitivity, MDR1
- Neonatal Encephalopathy with Seizures Aliases: NEWS
- Osteochondrodysplasia Aliases: Skeletal dwarfism, OCD
- Progressive Retinal Atrophy, Progressive Rod-Cone Degeneration Aliases: PRA-PRCD, PRCD
- Progressive Retinal Atrophy, Rod-Cone Dysplasia 4 Aliases: PRA-rcd4
- Von Willebrand Disease I Aliases: Pseudohemophilia, Vascular hemophilia, von Willebrand disease type 1, von Willebrand’s disease, VWDI
Maremma Sheepdog:
- Degenerative Myelopathy Aliases: Canine degenerative myelopathy, DM
Bordoodle:
- Chondrodystrophy (CDDY and IVDD Risk) with or without Chondrodysplasia (CDPA)
- Collie Eye Anomaly Aliases: Choroidal hypoplasia, CEA, CH
- Degenerative Myelopathy Aliases: Canine degenerative myelopathy, DM
- Dental Hypomineralization
- Ehlers-Danlos Syndrome (Poodle Type, Variants 1 and 2)
- GM2 Gangliosidosis (Poodle Type) Aliases: Sandhoff disease, Type 0 gangliosidosis
- Glaucoma (Border Collie Type) Aliases: BCG
- Goniodysgenesis and Glaucoma, Pectinae Ligament Dysplasia, PLD
- Hereditary Cataracts Aliases: Early-onset cataracts, Juvenile cataracts, HC, JC
- Hyperuricosuria Aliases: Urolithiasis, HUU (Hereditary Calcium Oxalate Urolithiasis Type 1)
- Intestinal Cobalamin Malabsorption (Border Collie Type) Aliases: Cobalamin deficiency, Cubilin deficiency, Imerslund-Grasbeck syndrome, I-GS
- Multidrug Resistance 1 Aliases: Ivermectin sensitivity, MDR1 gene defect, Multidrug sensitivity, MDR1
- Myotonia Congenita (Australian Cattle Dog Type) Aliases: Congenital myotonia, Inherited myotonia, Myotonia, Myotonia hereditaria
- Neonatal Encephalopathy with Seizures Aliases: NEWS
- Neuronal Ceroid Lipofuscinosis 5 (Australian Cattle Dog/Border Collie Type) Aliases: Amaurotic idiocy, Batten disease, NCL, NCL5
- Osteochondrodysplasia Aliases: Skeletal dwarfism, OCD
- Primary Lens Luxation Identified in Border Collies
- Progressive Retinal Atrophy, Progressive Rod-Cone Degeneration Aliases: PRA-PRCD, PRCD
- Progressive Retinal Atrophy, Rod-Cone Dysplasia 4 Aliases: PRA-rcd4
- Sensory Neuropathy (Border Collie Type) Aliases: SN
- Trapped Neutrophil Syndrome Aliases: Cohen syndrome, TNS
- Von Willebrand Disease I Aliases: Pseudohemophilia, Vascular hemophilia, von Willebrand disease type 1, von Willebrand’s disease, VWDI
Updated 10/7/2025
By: Kara Marx



